CRO Services

Discovery Chemistry Services

Accelerate your drug discovery programs with Astinova's expert medicinal chemistry team — from hit identification through optimized leads ready for development.

AI-driven drug design and SAR exploration panel with property prediction and analog matrix.
AI Design And SAR Cycles

Discovery Services Portfolio

Comprehensive medicinal chemistry and custom synthesis capabilities to support your discovery stage programs.

Medicinal Chemistry

Expert medicinal chemistry support for your hit-to-lead and lead optimization programs, including analog design, synthesis, and SAR interpretation.

  • Design and synthesis of analogs
  • Bioisostere exploration
  • SAR interpretation support
  • Property optimization (ADMET)

Hit-to-Lead Optimization

Rapid synthesis of focused libraries and analogs to define SARs, optimize potency, and identify lead candidates.

  • Focused library synthesis
  • Potency optimization
  • Selectivity profiling support
  • Metabolic stability improvements

SAR Optimization Campaigns

Systematic SAR exploration campaigns with rapid analog synthesis and comprehensive analytical characterization.

  • Systematic position-by-position SAR
  • Parallel synthesis capabilities
  • Multi-parameter optimization
  • Regular data review & design iteration

Custom Synthesis

Bespoke synthesis of challenging molecules, novel scaffolds, reference standards, and specialized intermediates.

  • Novel scaffold synthesis
  • Reference standards
  • Labeled compounds (stable isotopes)
  • Multi-mg to gram quantities

Scaffold Design

Design and synthesis of novel scaffolds with built-in vectors for efficient SAR exploration and property optimization.

  • Core scaffold identification
  • Ring system diversification
  • Conformational constraint design
  • IP space exploration

Fragment-Based Drug Design

Synthesis and elaboration of fragment hits, fragment-to-lead chemistry, and linker-based fragment merging strategies.

  • Fragment library synthesis
  • Fragment growing & merging
  • Biophysics-driven design support
  • Structure-guided elaboration

Discovery Capabilities Overview

Our discovery chemistry team is equipped to handle diverse synthetic challenges.

C Chemistry Capabilities

Multi-step synthesis (up to 20+ steps) Expert
Asymmetric synthesis Expert
Heterocyclic chemistry Expert
Cross-coupling chemistry (Pd, Cu, Ni) Expert
Protecting group strategies Expert
Functional group transformations Expert

A Analytical Capabilities

NMR (1H, 13C, 2D COSY/HSQC/HMBC) Routine
LC-MS / HRMS confirmation Routine
HPLC purity analysis (>95% standard) Routine
Chiral HPLC analysis & separation Routine
Preparative HPLC purification Routine
Optical rotation, IR spectroscopy Routine

How We Work With You

A collaborative, science-driven engagement model designed around your program needs.

1

Program Briefing

Share your target, chemistry challenge, timeline, and desired quantities. We sign an NDA on day one.

2

Proposal & Plan

We propose a synthesis strategy, timeline, milestones, and deliverables within 48 hours.

3

Active Synthesis

Weekly updates, real-time data sharing, and collaborative design iterations throughout the campaign.

4

Delivery & Report

Compounds delivered with full characterization data and a detailed synthesis report.

Ready to Start Your Discovery Campaign?

Share your chemistry challenge and we'll get back to you within 48 hours with a proposal.

Request a Proposal