Chemical Catalog

Chemical Catalog & Custom Building Blocks

Astinova maintains a growing portfolio of small-molecule and advanced-modality building blocks, intermediates, and custom synthesis standards — the chemistry behind our AI-augmented, PhD-verified route design — available on request.

Publication-style plate of advanced modality building block molecules and linker motifs.
Publication-Style Molecule Plate
Full catalog available on request. Contact us to discuss specific compound needs.

Catalog Categories

Our catalog covers key compound classes for advanced modality drug discovery programs.

PROTAC Building Blocks

E3 Ligase Ligands

  • › VHL ligand (VH032 analog)
  • › Pomalidomide (CRBN)
  • › Lenalidomide derivatives
  • › Bestatin analogs (IAP)
Available on request

PEG Linkers

  • › PEG1–PEG12 diamine
  • › Boc-PEG-acid series
  • › NH2-PEG-NHS ester
  • › Azide-PEG-amine
Available on request

Alkyl & Mixed Linkers

  • › C2–C8 diamine linkers
  • › Piperazine linkers
  • › Piperidinyl linkers
  • › Mixed alkyl-PEG hybrids
Available on request

Reactive Handles

  • › NHS-ester activated acids
  • › Alkyne-bearing warheads
  • › Azide-functionalized components
  • › Amine-reactive probes
Available on request

ADC Components

Cleavable Linkers

  • › Val-Cit-PABC linkers
  • › Disulfide-based linkers
  • › Acid-labile hydrazide linkers
  • › β-glucuronide linkers
Available on request

Non-Cleavable Linkers

  • › Maleimide-caproyl linkers
  • › NHS-PEG4-maleimide
  • › Thioether stable linkers
  • › Bifunctional crosslinkers
Available on request

Payload Analogs

  • › Auristatin analogs (MMAE-type)
  • › Maytansinoid analogs (DM1-type)
  • › Calicheamicin analogs
  • › Novel cytotoxin intermediates
Custom synthesis

Conjugation Handles

  • › Thiol-reactive maleimides
  • › Amine-reactive NHS esters
  • › Aldehyde-reactive hydrazides
  • › Click chemistry handles
Available on request

Small Molecule Building Blocks

Scaffolds & Fragments

  • › Saturated heterocyclic cores
  • › Spirocyclic building blocks
  • › sp3-rich fragment sets
  • › Functionalized azetidines & pyrrolidines
Available on request

Advanced Intermediates & KSMs

  • › Custom key starting materials
  • › Late-stage NCE intermediates
  • › Generic-API intermediates (patent-grounded)
  • › Multi-step custom synthesis
Custom synthesis

Coupling Partners

  • › Boronic acids & esters (Suzuki)
  • › Halogenated aromatic & heteroaromatic cores
  • › Amide-coupling reagents (HATU, HBTU analogs)
  • › Activated ester intermediates
Custom synthesis

Chiral & Catalysis Reagents

  • › Chiral ligands & auxiliaries
  • › Asymmetric hydrogenation catalysts
  • › Enantiopure amine & alcohol synthons
  • › Organocatalysts (NHC, Brønsted acid)
Custom synthesis

Chiral Building Blocks

Chiral Auxiliaries

  • › Oxazolidinone-based auxiliaries
  • › Evans auxiliary analogs
  • › Camphorsultam derivatives
  • › Sulfinyl chiral controllers
Available on request

Asymmetric Intermediates

  • › Enantiopure amino alcohols
  • › Chiral prolinol derivatives
  • › Asymmetric epoxide building blocks
  • › Enantiopure lactams
Custom synthesis

Atropisomeric Scaffolds

  • › Axially chiral biaryl compounds
  • › BINAP/BINOL analogs
  • › Atroposelective PROTAC scaffolds
  • › Resolved atropisomers
Custom synthesis

Macrocycle Precursors

  • › Chiral linear macrocycle precursors
  • › Pre-cyclization intermediates
  • › High-dilution cyclization substrates
  • › RCM diene precursors
Custom synthesis

Request the Full Catalog

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