Breadth Beyond Small Molecules

Advanced Modality Chemistry

Route design and expert-verified chemistry across the modalities driving modern drug discovery — small molecules, PROTACs & molecular glues, ADC components & ionizable lipids, and hard stereochemistry — every route verified by a PhD synthetic chemist, with honest scale reporting.

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Platform 01

Small Molecules

The core of our work: designing and verifying routes to small-molecule NCEs and commercial APIs across every scale.

  • ›NCE route design & scaffold / fragment analysis
  • ›Multi-scale routes: lab · kilo · commercial
  • ›Generic API routes (originator-patent-grounded)
  • ›Cost, hazard & IP-aware route selection

Representative small-molecule NCE

Small-molecule NCE structure

CRBN ligand (pomalidomide-type)

CRBN ligand structure
Platform 02

PROTACs & Molecular Glues

Targeted protein degradation demands precise, convergent chemistry. We design and verify degrader routes end to end.

  • ›Warhead – linker – E3 ligand design & route design
  • ›E3 ligase ligands: VHL (VH032-class), CRBN (thalidomide / lenalidomide / pomalidomide analogs), IAP (bestatin-based)
  • ›Linker libraries: PEG, alkyl, piperidinyl / piperazinyl, rigid & semi-rigid
  • ›10–20+ step convergent assembly; ternary-complex & exit-vector SAR support
Platform 03

ADC Components & Ionizable Lipids

Linker-payload components and ionizable LNP lipids, delivered as intermediates and components with honest, per-molecule scale caps.

  • ›Cleavable linkers: val-cit-PABC, acid-labile, disulfide, β-glucuronide
  • ›Non-cleavable linkers: maleimide-caproyl, thioether
  • ›Cytotoxic payload analogs (auristatin MMAE / MMAF-type, maytansinoid DM1 / DM4-type) — custom synthesis
  • ›Ionizable LNP lipids via convergent fragment coupling — clinical-grade kg feasible; research-only at gram scale

Representative ionizable lipid

Representative ionizable lipid structure

Chiral diamino-ester (2 centres)

Chiral diamino-ester structure
Platform 04

Hard Stereochemistry & Macrocycles

Multi-centre chiral targets and macrocycles that defeat single-polarity thinking — solved with divergent disconnection mapping.

  • ›Multi-chiral-centre building blocks
  • ›Divergent disconnection maps (bond × polarity × chiral source)
  • ›Asymmetric methods: aza-Henry, asymmetric hydrogenation
  • ›Kinetic resolution & racemise-and-recycle; macrolactamization / atropisomer control

All advanced-modality work follows the same expert-in-the-loop verification and honest scale reporting as our small-molecule routes. Where a chemistry has a realistic scale ceiling, we state it up front.

Let's design your next route.

Bring us a target — known or novel. We return scale-matched, costed, verified routes your team can act on.

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